While we focused our present study on the R6/2 mice, other transgenic mouse strains with a cold-sensitive body temperature phenotype such as the N171-82Q model of HD [10] and the mutant SOD1 model of amyotrophic lateral sclerosis [27] should also be investigated with respect to BAT structure, distribution and function in vivo. This evidence concerns the gene SOD1 and Huntington disease.