Previously we showed that there was a predominant Th2 phenotype in gastric cancer patients, and it was believed that the Th2 associated cytokines IL-4, IL-13, IL-6 and transcriptional factors GATA3 might closely be related to the polarization of M2 and MDSCs,and fostered an immunosuppressive environment in cancer patients. The gene discussed is IL4; the disease is gastric cancer.