For example, in case of sense lncRNA NONHSAG044354 associated with IBD and T1D candidate gene BACH2, we observed significant tissue-specific cis-eQTL signal but only in whole blood based on gene SNP association for the structure-disruptive SNP rs3757247 and BACH2. The propensity of variation in gene expression patterns observed between and within species is strongly determined by the adaptive changes in the gene regulation mechanisms [61]. This evidence concerns the gene BACH2 and inflammatory bowel disease.