However, when we further examined MerTK+CD64+ macrophages for expression of F4/80 and CD11c, which can be used to distinguish subsets of macrophages within tissues [19], we found that a population of F4/80+CD11chi cells was markedly increased as a result of infection and depleted by DT treatment in infected CCR2-DT mice (Fig. 6A). Here, CCR2 is linked to infection.