NPPB and hypertensive disorder: After enzymatic cleavage, it is released into the circulation system in equimolar proportions as the hormonally active BNP and the inactive N-terminal fragment (N-terminal-pro-B-type natriuretic peptide, NT-proBNP).The expression of NT-proBNP is affected by several variations, such as age, gender, hypertension, renal function and thyroid function [1].