Research to date indicates that NOX1 is upregulated during vascular injury, atherosclerosis, and hypertension [43], [44], [46], [47], [48]; NOX2 is upregulated during atherosclerosis and vascular injury [44], [46], [49], [50]; NOX4 expression is upregulated during the re-differentiation phase of neointimal formation and the late stages of restenosis [9], [44], [46]; and NOX5 is upregulated during atherosclerosis [43], [51]. The gene discussed is NOX4; the disease is atherosclerosis.