The novel findings of our study, combined with results from previous studies showing KCNN4 plays a key role in regulating SMC phenotypic modulation [7] and post-angioplasty restenosis [18], strongly support a role for NOX5 regulation of KCNN4 in the development of atherosclerosis and restenosis. The gene discussed is KCNN4; the disease is atherosclerosis.