Inhibition of NOX1, implicated in the pathogenesis of restenosis and atherosclerosis, has been shown to significantly inhibit neointimal formation [26], [43], [48], [91], and unlike NOX2 and NOX4, has been shown to be upregulated by bFGF in rat and mouse aortic SMCs [92]. This evidence concerns the gene NOX4 and atherosclerosis.