In this regard, it is interesting to note that Glut1 expression has been observed to be elevated in oncogenic K-Ras-positive human lung adenocarcinomas [31], suggesting that our results may also be translated in human malignancy.The tumor-promoting activity of hyperglycemia on tumor-initiating BASCs can be mediated by direct and indirect mechanisms. This evidence concerns the gene KRAS and Hyperglycemia.