KRAS and neoplasm: Recently, it has been shown that K-Ras-mutated cells show rapid upregulation of specific glycolytic metabolic enzymes (e.g. the glucose transporter Glut1/Slc2a1) and their pathways prior to any discernible biological impact (e.g., morphological or proliferative changes), a finding consistent with the active control of tumor cell metabolism by oncogenic K-Ras [30].