Subjects with chronic T. cruzi infection with severe cardiomyopathy also displayed lower frequencies of T. cruzi-responsive IFN-γ-producing T cells and lower levels of IFN-γ production compared to subjects with no signs of heart disease [8], [13], [16], leading us to propose that long-term parasite persistent might dampen parasite specific T cell responses [44]. This evidence concerns the gene IFNG and heart disorder.