The splenocytes of vaccinated hamsters receiving liposomal rCPC and cocktail of three liposomal CPs showed higher IFN-γ, IL-2, TNF-α and IL-12 mRNA expression than all other groups but appreciable downregulation of macrophage deactivating cytokines like IL-4, IL-10 mRNAs, before and after infection (Fig. 7). Here, TNF is linked to infection.