In this meta-analysis, we found that individuals with AG/GG genotype had a higher risk of developing cancer under all four models in HSP70-2 polymorphism; besides, in the stratified analyses by ethnicity, cancer type, and source of control, we found that G allele carriers had a higher risk of cancer than AA genotype carriers in Asians, Africans, hepatocellular carcinoma, and population-based population. This evidence concerns the gene HSPA1B and hepatocellular carcinoma.