Concerning the relationship between inflammation and netrin-1 van Gils et al. in 2010 established that netrin-1 inhibited macrophage migration via UNC5B, in case that the presence of an atherosclerotic plaque and that deletion of netrin-1 in myeloid cells severely reduced atherosclerosis lesion size [45, 46]. The gene discussed is NTN1; the disease is atherosclerosis.