During the trek, in the two DM2 subjects treated with insulin, it was necessary to avoid hypoglycemic episodes to reduce the daily insulin units by 45% and 60%; 14 out of 19 subjects treated for hypertension reduced the antihypertensive drugs (30% less calcium-antagonists and 65% less diuretics) because of the progressive reduction of systolic and diastolic blood pressure. The gene discussed is INS; the disease is hypertensive disorder.