In addition, they found that the overexpression of miR-1246 reduced apoptosis, by interfering with DYRK1A (Down syndrome-associated protein kinase) [38], that is directly implicated in the resistance of cancer cells to proapoptotic signals and controls various pathways that regulate proliferation, migration, and inhibition of apoptosis, causing a very aggressive behavior of cancer [39]. Here, DYRK1A is linked to cancer.