TGM2 and glomerulosclerosis: Huang et al. have demonstrated inhibition of TG2 with NTU281 in uninephrectomized streptozotocin-induced diabetic rats, where TG2 inhibition significantly reversed the increased serum creatinine and albuminuria in the diabetic rats and also led to fivefold decrease in glomerulosclerosis and a sixfold reduction in tubulointerstitial scarring [40].