Some investigators have concluded that the leukocytosis is in response to the myeloma because monoclonal B-cell clones in myeloma can produce cytokines which are able to activate stromal cells to produce IL-6, IL-7, and IL-11 to stimulate T lymphocytes to produce IL-3 and GM-CSF [6]. Here, CSF2 is linked to Increased total leukocyte count.