RXR agonists have also been shown to activate PPARα-inducible genes and lower triglycerides and raise HDL levels in vivo[26], reduce atherosclerosis in apoE knockout mice [27] and activate RXR:PPARγ heterodimer to reduce hyperglycemia, hypertriglyceridemia and hyperinsulinemia [28]. Here, PPARG is linked to Hyperglycemia.