A number of carcinogenesis studies have shown that levels of Cx43 or other connexin GJs are downregulated in cancer cells; decreased GJIC is considered as an important factor in oncogenesis [98–100] as well as the increased cytoplasmic pool of Cxs when Cx protein synthesis remains unchanged but connexon trafficking to the plasma membrane is inhibited due to disruption of the actin network [76]. The gene discussed is GJA1; the disease is cancer.