General toxicity related to chloride channel deregulation has been suggested to underlie the high micromolar toxicity of Ivermectin for liquid tumor cellsin vitro (Drinyaevet al, 2004; Sharmeenet al, 2010) and might complicate the treatment of WNT-TCF-dependent brain diseases since Ivermectin can affect glutamate-gated and other Cys-loop ion chloride channels (Kokozet al, 1999; Hibbs & Gouaux, 2011; Lynagh & Lynch, 2012). This evidence concerns the gene HNF4A and neoplasm.