CCND1 and malignant colon neoplasm: Treatment of DLD1 and Ls174T colon cancer cellsin vitro with Ivermectin led to a dose-dependent inhibition of the levels of two C-terminal phosphoforms of β-CATENIN: Phospho-Ser552 and Phospho-Ser675 and to the repression of CYCLIN D1 (Fig6A, Supplementary Fig S7).