The strong downregulation of the expression of the intestinal stem cell genesASCL2 andLGR5 (van der Flieret al, 2009; Scheperset al, 2012; Zhuet al, 2012b) by Ivermectin and Selamectin (Fig2D) raised the possibility that these drugs could affect WNT-TCF-dependent colon cancer stem cell behavior. This evidence concerns the gene HNF4A and colonic neoplasm.