We have shown that blocked WNT-TCF activity by expression of dnTCF4 in human colon cancer cells and primary xenografts in mice (including tumors generated by grafted Ls174T cells and primary CC14, CC36 cells) does not generally lead to arrested growth or cell death, with the exception of DLD1 cells (Varnatet al, 2010). The gene discussed is HNF4A; the disease is malignant colon neoplasm.