This effect can help explain the phenotype of Ivermectin-treated cells since P-Ser552- and P-Ser675-β-CATENIN show enhanced transcriptional activity in cooperation with TCF factors and are essential for WNT signaling in colon cancer cells (Hinoet al, 2005; Taurinet al, 2006; Fanget al, 2007; Zhuet al, 2012a). The gene discussed is HNF4A; the disease is malignant colon neoplasm.