HNF4A and cancer: However, with the aim to find blockers of WNT-TCF responses in cancer, we implemented two key modifications: i- a reliable dynamic range determined by activated β-CATENIN as the activating pole and activated β-CATENIN plus dominant-negative TCF (dnTCF) as the repressing pole, and ii- sine qua non mimicry of genetic blockade by dnTCF activity for any hit.