Finally, five studies were included (Fig. 1): Subramanian et al. [12]; the CATT study [2]; the Alternative Treatments to Inhibit VEGF in Age-Related Choroidal Neovascularization (IVAN) study [3]; the Multicentre Anti-VEGF Trial in Austria (MANTA) [5]; and the French study group Avastin versus Lucentis for Neovascular AMD (GEFAL) [4]. Here, VEGFA is linked to age-related macular degeneration.