Carlino et al. [33] , recently published that combinatorial blockade with relatively high concentrations of the ERKi, Vx-11e (10 μM) and PI3K/AKT inhibitor BEZ235 (2 μM) more completely induced cell death in BRAF-inhibitor resistance melanoma cell lines compared to the combination of trametinib (10nM) and BEZ235. The gene discussed is BRAF; the disease is melanoma.