BRAF and melanoma: Since resistance to BRAFi or MEKi is highly dominated by the reactivation of the MAPK pathway (acquisition of RAS mutations, BRAFV600 amplifications, MEK mutations, BRAFV600E amplification or the Δ2-8 BRAF splice variant [30] or secondary RTK overexpression), SCH772984 is a promising strategy to delay or revert resistance and has demonstrated activity in our BRAFi-resistant melanoma cell lines with reactivation of the MAPK pathway mechanism of resistance.