For example, activation of PI3K/AKT pathway was detected in radioresistant prostate cancer cells with enhanced EMT/CSC phenotypes, and the combination of PI3K inhibitor with radiotherapy induced more apoptosis in radioresistant cells, along with decreased expression of EMT/CSC markers and PI3K/AKT signaling proteins [26]. This evidence concerns the gene PIK3CA and Familial prostate cancer.