Shh expression was positive in 25 (62.5%) of the 40 NSCLC specimens, and Gli1, LYVE-1 and VEGF-D were positive in 20 (50.0%), 11 (27.5%) and 20 (50.0%) of the 40 specimens, respectively. The gene discussed is LYVE1; the disease is non-small cell lung carcinoma.