GBA2 and cystic fibrosis: This contention is supported by the findings that: i) treatment of P. aeruginosa infected CF bronchial cells with Genz-529648, a potent inhibitor of GBA2, reduced the extent of inflammation; ii) the IC50 value of the anti-inflammatory effect of Genz-529648 was similar compared to the effect reported toward inhibiting GBA2 activity (33); iii) treatment of CF bronchial cells with miglustat or Genz-529648 inhibited GBA2; and iv) inhibition of GBA2 by siRNA lowered the expression of IL-8.