Mechanistically, LOX family members have been suggested to promote metastasis by modulating the extracellular matrix surrounding the tumour, which can lead to the activation of focal adhesion kinase (FAK), SRC, MAPK, and integrins, as well as by the induction of an epithelial-mesenchymal transition (EMT) via SNAI1 [1]. Here, LOX is linked to neoplasm.