Enrichment of KEGG pathways, GO analysis and bibliographic study showed that UVA1 modulated the expression of genes involved in cancer, such as oncogenes that were up-regulated (FOS, FOSB, MAFG, ABL2, MET, ETS1), tumor suppressors that were down-regulated (FETB and RARRES1), cathepsin genes (CTSH, CTSL1) or PTGS2 gene that have a crucial role in the development of skin cancers [64], [65]. The gene discussed is CTSL; the disease is skin cancer.