KCNH2 and Ventricular arrhythmia: [3] Febrile disease has been associated with ventricular arrhythmia in LQTS-2. [11] Mechanistically, Kv11.1 subunits are very sensitive to changes in temperature with increased current density upon elevated temperature, [12] but at the same time reduced membrane trafficking. [1] Furthermore, fever may increase dispersion of refractoriness and precipitate early after-depolarisations that can trigger polymorphic ventricular tachycardia (VT) and sudden cardiac death (SCD) [13].