KCNH2 and cardiac arrhythmia: [11] These authors documented shortened QTc in healthy probands, but a linear increase in QTc with temperature rise in patients. This study convincingly illustrated reduced expression of KCNH2 subunits with elevated temperature, linking it with arrhythmia precipitation. Another study in canine ventricular wedges documented an additional pro-arrhythmic increase in transmural dispersion of refractoriness under experimental conditions of reduced IKr density. [13] This led to prominent triggering of early after-depolarizations.