Thus, α-MSH performs two types of biological functions based on its (i) hormonal effects such as melanin synthesis, secretion of sebum, regulation of temperature, control of pain, and regulation of behavior involving sex, feeding, and learning and (ii) immunomodulatory effects such as the cure of several inflammatory conditions of brain (meningitis, vasculitis, etc.)and peripheral organs (arthritis, colitis, etc.)and immunosuppression [2, 6, 7, 51]. This evidence concerns the gene STAMBP and arthritic joint disease.