Charizopoulou et al. identified a sequence polymorphism in the PDZ domain of Gipc3 as the cause of progressive sensorineural hearing loss (age-related hearing loss 5, ahl5) and audiogenic seizure susceptibility (jams1) in BLSW mice and they screened panels of families of Dutch and Indian origin presenting with autosomal recessive nonsyndromic hearing impairment to examine whether mutations in GIPC3 underlie human sensorineural hearing loss [8]. This evidence concerns the gene GIPC3 and sensorineural hearing loss disorder.