However, in two recent randomized controlled studies [the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) trial and The Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR) Thrombolysis in Myocardial Infarction (TIMI) 53 trials], DPP-4 inhibitor therapy in high risk patients with type 2 diabetes did not show a CV protective effect [98, 99]. Here, DPP4 is linked to type 2 diabetes mellitus.