Following a 24 hr treatment exposure to 150 μM CoCl2 alone +SA mammary tumor cells displayed little change in their the relative levels of MEK, phospho-MEK1/2, ERK1, ERK2, or phospho-ERK1/2 as compared to the +SA mammary tumor cells in the vehicle-treated control group (Figure 6). The gene discussed is MAP2K1; the disease is breast cancer.