EGFR and cancer: In addition to this action, recent evidence indicates that EMT changes develop a resistance to a several anti-cancer agents such as EGFR-tyrosine kinase inhibitor, cisplatin, gemcitabine, and 5-FU (Singh & Settleman 2010; Thomson et al. 2005; Frederick et al. 2007; Zhuo et al. 2008; Arumugam et al. 2009; Wang et al. 2009).