KCNJ10 and Abnormality of metabolism/homeostasis: SeSAME (seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance) or EAST (epilepsy, ataxia, sensorineural deafness, and tubulopathy) syndrome is caused by mutations of the K (+) channel KCNJ10 (Kir4.1) gene, which is an autosomal recessive disease [5, 6].