We detected p21 induction together with p53 and Puma increase in CML-T1 cells after both DAC + SAHA and DAC + SAHA + ATRA treatment, enhanced p21 expression was detected also in ATRA-treated CML-T1 (Figure 6). This evidence concerns the gene TP53 and chronic myelogenous leukemia, BCR-ABL1 positive.