More recently, Gutiérrez-Rojas et al. showed that in rats with streptozotocin-induced T2D amylin increased osteoblast number and OCN expression in long bone and normalized trabecular structure; on the contrary, insulin resistant rats treated with amylin did not present any apparent osteogenic effect in the femur, although both OCN and OPG/RANKL ratio were increased in the tibia. Here, INS is linked to type 2 diabetes mellitus.