Therefore, one would have to speculate that, although helminth infections and allergens would stimulate cells with the same basic N− repertoire, allergens would also recruit cells with the more sophisticated N+ repertoire, leading to the production of high-affinity IgE antibodies, whereas helminths would lead to the production of low-affinity, less mutated, multireactive N– encoded IgE antibodies. This evidence concerns the gene IGHE and helminthiasis.