In A549 cells, nuclear-localized ATF6 was observed (Umareddy et al., 2007); however, no activating events can be detected in human fibrosarcoma 2fTGH cells, therefore, GPR78 upregulation may be mediated in an ATF6-independent fashion (Pena and Harris, 2011). The gene discussed is ATF6; the disease is fibrosarcoma.