FMO5 and hypertensive disorder: Potential sources of ROS that are involved in the pathogenesis of hypertension include: uncoupled NOS which generates superoxide rather than protective NO (Nishino et al., 2008); activation of NADPH-oxidase (Adlam et al., 2007); xanthine oxidoreductase and mitochondrial respiratory enzymes (Sedeek et al., 2009).