Although these studies support a mechanism by which resveratrol can limit vasoconstriction and ameliorate hypertension, they must be interpreted with caution since the aorta is a conduit vessel which does not contribute to vascular resistance and any sustained reduction in blood pressure likely also involves some renal effect as emphasized earlier, such as amelioration of renal vascular AT1 receptor expression and renovascular vasoconstriction. The gene discussed is AGTR1; the disease is hypertensive disorder.