These Tg mice, by harboring three human dementia-related transgenes, APPswe, PS1M146V, and tauP301L, reproduce key AD-related features like amyloid beta- (Aβ) and tau-dependent pathology, as well as an age-dependent development of synaptic dysfunction and LTP deficits (Oddo et al., 2003). This evidence concerns the gene MAPT and Alzheimer disease.