Comparison between young 3xTg-AD vs. age-matched WT mice revealed that Tg-AD animals showed a significant up-regulation of GluA3 (p = 0.039) and GluA4 (p = 0.007) whereas no changes were detected for GluA1 and GluA2 (Figure 1C). The gene discussed is GRIA3; the disease is Alzheimer disease.