Comparison between old 3xTg-AD mice vs. age-matched WT animals showed, in the AD mice, a significant down-regulation of GluA2 (p = 0.038) and GluA3 (p = 0.005) while expression levels of GluA1 and GluA4 were unchanged (Figure 1D; Table S2). Here, GRIA1 is linked to Alzheimer disease.