In 3xTg-AD mice, aging promoted a statistically significant reduction of all the AMPAR subunits (GluA1, p = 0.045; GluA3, p = 0.047; GluA4, p = 0.011; Figure 1B) with the exception of GluA2 that remained stable (Table S2). This evidence concerns the gene GRIA4 and Alzheimer disease.