Further, some studies pointed out that this protein may be produced in the brain in response to different stress stimuli (Lee et al., 2002; Borsody et al., 2006; Zhao et al., 2009), and increased level of Hpt was found in cerebrospinal fluids (CSF) from patients with AD (Johnson et al., 1992), or other neurodegenerative diseases such as Parkinson' and Huntington's disease (Argüelles et al., 2010; Huang et al., 2011). The gene discussed is MRS2; the disease is Alzheimer disease.