APOE and Alzheimer disease: As ApoE plays a key role in modulating brain cholesterol trafficking, and dysregulation of cholesterol balance in brain is increasingly being correlated to AD (Vance, 2012), the evaluation of inflammatory- and non-inflammatory players, able to influence ApoE key activity in cholesterol or Aβ metabolism might represent an alternative approach to elucidate the link among AD pathogenesis, ApoE, and cholesterol metabolism.