PCSK9 and acute coronary syndrome: The PCSK9 monoclonal antibody alirocumab has been shown to strongly lower LDL-C and non-HDL cholesterol (HDL-C) alone and on top of statin treatment (23–26) and is currently in phase 3 clinical development, which includes a large CVD outcome trial in hypercholesterolemic patients with relatively recent acute coronary syndrome treated with high-dose statins (42).