BRD2 and polycystic ovary syndrome: Further, FSH and/or IGF-1-induced progesterone secretion in cultures of GCs from 8- to 10-mm-sized unluteinized follicles from women with PCOS was significantly lower than control GCs, supporting inherent perturbation in the steroidogenic capacity of PCOS GCs (Erickson et al., 1992).