TNFRSF11A and neoplasm: Denosumab, a fully human monoclonal antibody that specifically inhibits normal and tumor-associated bone lysis by preventing RANKL-mediated formation and activation of multinucleated osteoclasts or giant cells from RANK-positive mono-nuclear preosteoclasts and macrophages [21], has been proved to be able to reduce the number of RANK-positive giant cells and proliferative stromal cells [15].