IFNB1 and myeloid sarcoma: In some countries, like the USA, Switzerland, Australia and Russia, fingolimod is approved as a first line treatment while in Europe and Canada fingolimod is a second line therapy especially for those patients who are non-respondent to at least one other DMT like interferon beta (IFNβ) or glatiramer acetate (GA) or who have rapidly evolving MS [1]–[3].