Indeed severe malarial anaemia (SMA), defined as as anaemia with haemoglobin (Hb) concentration of <5 g/dL with P. falciparum asexual parasitemia, in the absence of any other or additional identifiable cause of anaemia [3], is the most widespread complication of Plasmodium falciparum infection, especially among children (WHO, 2000). The gene discussed is GSTM1; the disease is anemia (phenotype).