CD133+SW620 (moderate expression of surface ULBP3), CD133−SW620 (high expression of surface ULBP3), and CD133−SW620ULBP3-siRNA (no/low expression of surface ULBP3; Figure 3A) tumor cells were used as target cells, and NK cells were freshly isolated from healthy volunteers for use as effector cells in cytotoxicity assays. This evidence concerns the gene ULBP3 and neoplasm.