Strikingly, the only genes whose expression was higher in the DCM functional network were the importin, IPO5, and the nucleoporin, NUP153. A previous study by our group showed that the protein levels of IPO5 and NUP153 increase in patients with HF [12], [13], and thus, these proteins could be predominantly controlling the nucleocytoplasmic transport in DCM, in conjunction with XPO1. This evidence concerns the gene IPO5 and familial dilated cardiomyopathy.