PTK2B and myocardial infarction: Furthermore, a study by Hart et al suggested the role of Pyk2 in promoting the deterioration of the left ventricular remodeling post- myocardial infarction wherein, the adenovirus-mediated expression of a dominant negative inhibitor of Pyk2 signaling after myocardial infarction (MI) in rats resulted in improved survival, increased LV function, and altered expression of myosin heavy chain isozymes, indicating an attenuation of LV remodeling post-MI [36].