Collectively, our findings revealed that the genes DDX3X (DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked), KPNA2 (Karyopherin alpha 2 (RAG cohort 1, Importin alpha 1), and PTK2B (Protein tyrosine kinase 2 beta) were exclusively related to ICM, while SMURF2 (SMAD specific E3 ubiquitin protein ligase 2), NUP153 (Nucleoporin 153 kDa), IPO5 (Importin 5), RANBP3 (RAN binding protein 3), NOXA1 (NADPH oxidase activator 1), and RHOJ (Ras homolog family member J) were involved in DCM. This evidence concerns the gene IPO5 and familial dilated cardiomyopathy.