These findings suggested that the leader in “Complement and coagulation cascades” pathway may be a communication hub into other pathways, which play an important role in breast cancer [46], [47].Some dysfunctional genes (including KRAS, F11R, JAM3 and PDGFRA) with different molecular alterations have participated in multiple pathways (such as “MAPK signaling pathway”, “Cell adhesion molecules (CAMs) and Pathways in cancer”), which suggests that these leaders serve as exchange centers for the cross-talk among the pathways. Here, JAM3 is linked to breast carcinoma.