In the present study, we investigated the role of KLF4 in ovarian cancer cells using a doxycycline (Dox)-dependent KLF4-inducible lentiviral vector (Tet-on) and found that inducible overexpression of KLF4 reduced cell proliferation, migration, and invasion through promoting MET in ovarian cancer cells. This evidence concerns the gene MET and ovarian carcinoma.