In this context, we have previously shown that activated MS B cells secrete abnormally high levels of the pro-inflammatory cytokines lymphotoxin (LT), tumor necrosis factor (TNF)α and IL-6, compared to B cells of healthy subjects (HS) [5], [11], and we have linked these abnormal B cell cytokine responses with abnormal (T helper) Th1 and Th17 T cell responses in both MS and EAE. This evidence concerns the gene LTA and myeloid sarcoma.