Here we demonstrate, for the first time, that HLXB9 is expressed in a specific and restricted period during invitro human neuronal differentiation in the SK-N-BE neuroblastoma cell line, and that HLXB9 expression is associated with a change of its radial nuclear location, indicating HLXB9 as an early specific marker of neuronal cell differentiation, a process that implies a remodelling of the chromatin organization. This evidence concerns the gene MNX1 and neuroblastoma.